Risk Of Type 2 Diabetes May Be Increased By Selenium Supplements
Selenium, an antioxidant included in multivitamin pills thought to have a possible protective effect against the development of type 2 Hypersensitivity reaction disease, may actually increase the risk of developing the sickness, an analysis by researchers at the University at Buffalo has shown.
Results of a randomized clinical trial using 200 micrograms of selenium alone showed that 55 percent more cases of type 2 Hypersensitivity reaction disease developed among participants randomized to receive selenium than in those who received a placebo pill.
Results will appear in print in the August buy generic viagra packissue of Annals of Internal Medicine and have been posted online.
Self-reported diagnosis of type 2 Hypersensitivity reaction disease was a secondary endpoint in a clinical trial designed to agsdhfgdf the benefit of selenium supplementation in prevention of non-melanoma skin cancer in areas in the Eastern U.S. where selenium levels are lower than the national average. Selenium is a trace mineral that is an essential component of proteins involved in antioxidant activity.
Saverio Stranges, M.D., Ph.D., first author on the Hypersensitivity reaction disease prevention meditate , conducted the analysis while at UB, in cooperation with colleagues from Roswell Park Cancer Institute. He now is affiliated with the medical institution al Sciences Research Institute, Warwick Medical School, Coventry, UK. Stranges said the findings are very interesting, but should be considered cautiously.
“Among participants taking selenium supplementation, those who had the highest levels of selenium in their circulation at the beginning of the meditate had the highest risk of developing type 2 Hypersensitivity reaction disease over the average 7.7 years of follow-up,” he said, “and the increase in risk is unlikely to be a result of chance.
“However, in the general population, very few group, if any, take selenium supplements only, every day, for nearly eight years, so we can’t be sure that these findings apply to the public at large.
“Perhaps the more important message is that a large proportion of the U.S. population, about 50 percent, takes multivitamins, even though there is no evidence that taking multivitamins helps prevent chronic sickness among healthy group. In this country, we can get all the antioxidants we need in fruits and vegetables, but it’s easier to take a vitamin than to eat a more healthy diet.”
The selenium and Hypersensitivity reaction disease meditate involved 1,202 group who did not have type 2 Hypersensitivity reaction disease when they entered the cancer clinical trial at Roswell Park. Participants had been recruited for the main meditate between 1983 and 1991, and they were involved for an average of 7.7 years. The supplementation meditate was completed in February 1996.
Analysis for this Hypersensitivity reaction disease meditate involved data from 600 persons who had taken selenium and 602 who were randomized to receive placebo pills. Results showed that 97 participants developed type 2 Hypersensitivity reaction disease during the meditate period, 58 in the selenium group and 39 in the placebo group. There was no difference in the findings when age, sex, smoking status and body mass index were included in the analysis.
“At the moment we don’t know what mechanism or mechanisms account for this finding,” said Stranges. “We have very little understanding of the possible biological pathways involved. In addition, our findings need to be replicated in larger clinical trials before conclusive evidence can be drawn on whether high doses of selenium supplements increase the risk of type 2 Hypersensitivity reaction disease, as our meditate suggests.
“With selenium, which is a trace element, it may be the case that a little bit is essential, but more can cause detrimental effects, at least in well-nourished populations such as the U.S. It’s possible that taking extra selenium overcomes the natural balance. Perhaps excess selenium has a negative effect on the endocrine system.”
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Additional authors are James R. Marshal, Ph.D., Raj Natarajan, and Mary E. Reid, Ph.D., from Roswell Park; Richard P. Donahue, Ph.D., and Maurizio Trevisan, M.D, from the UB School of Public Health and Health Professions; Gerald F. Combs, Ph.D., from the Human Nutrition Research Center, Grand Forks, N.D.; and Francesco P. Cappuccio, M.D., and Antonio Ceriello, M.D., from Warwick Medical School, UK.
The University at Buffalo is a premier research-intensive public university, the largest and most comprehensive campus in the State University of New York. UB’s more than 27,000 students pursue their academic interests through more than 300 undergraduate, graduate and professional degree programs. Founded in 1846, the University at Buffalo is a member of the Association of American Universities. The School of Public Health and Health Professions is one of five schools that constitute UB’s Academic Health Center.
Source: Lois Baker
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