Pfizer’s Lipitor Provides Greater Reductions In Heart Attack, Stroke And Cardiovascular Procedures At An Overall Cost Savings Compared To Zocor
Pfizer Inc said today that a new economic analysis that compares outcomes for patients taking Lipitor to those taking Zocor shows that Lipitor patients had greater reductions in heart attacks, strokes and cardiovascular procedures. This provides a cost savings for payors in long-term hospitalizations and surgical costs.
The economic analysis examined the results from the IDEAL (Incremental Decrease in Endpoints Through Aggressive Lipid Lowering) trial to analyze the cost effectiveness of medical aid with Lipitor and Zocor (simvastatin) in Sweden, where Zocor is available generically as simvastatin. The IDEAL patients who received Lipitor (80 mg) achieved greater reductions in heart attacks, strokes and cardiovascular procedures compared to patients taking standard dose Zocor (20-40 mg).
The results also showed that one out of every six heart attacks,strokes or cardiovascular procedures could be avoided for coronary heart illness patients treated with intensive Lipitor medical aid above and beyond those treated with Zocor over 4.8 years.
These results were then applied to the U.S. health care system, with two key findings:
— Better efficacy was achieved in patients taking Lipitor, at a better overall value, compared to patients on standard Zocor medical aid; and Patients taking Lipitor achieved greater reductions in cardiovascular events, and the system had overall cost savings, compared to patients taking Zocor at the current U.S. price, and even when Zocor was discounted by 50 percent.
In the U.S., cardiovascular illness remains the nation’s leading health threat, and accounts for an estimated 500,000 recurrent heart attacks and 200,000 recurrent debilitating strokes annually.
“The economic impact of heart attacks and strokes in the U.S. alone totals nearly $403 billion in medical care and lost productivity annually,” said Dr. Peter Lindgren, Stockholm Health Economics. “This analysis suggests that the cost of using Lipitor versus generic simvastatin could represent a good value for money.”
“Even if the current U.S. price of Zocor were reduced by 75 percent, Lipitor patients could still achieve better cardiovascular outcomes at an increase to payors of less than one dollar a day,” said Dr. Gregg Larson, vice president cardiovascular medical at Pfizer. “While the economic cost of a stroke can be exorbitant, often entailing years of rehabilitation and supervised care the emotional impact on patients and their families is also devastating.”
The IDEAL economic analysis assessed the cost-effectiveness ofpreventing cardiovascular events for patients who took intensive Lipitor medical aid versus standard dose Zocor. The analysis compared the total cost per patient for 4.8 years in each medical aid group by calculating medication costs, the cost of hospitalizations associated with cardiovascular events and lost work days for the U.S. and for Sweden. The cost of Lipitor was compared to the cost of generic simvastatin for Sweden. For the U.S., the cost of Lipitor was compared to Zocor in three scenarios, including:
— Lipitor compared to the current U.S. price of Zocor (simvastatin);
— Lipitor compared to a 50percent reduction in the current U.S. price of Zocor;
— Lipitor compared to a 75percent reduction in the current U.S. price of Zocor
“IDEAL, which is one of a limited number of head to head statin medical aid trials showed that patients using intensive Atorvastatin medical aid compared with standard dose simvastatin suffered fewer cardiovascular events. The findings in IDEAL, along with otherness positive studies of intensive Atorvastatin medical aid against active medical aid comparitors such as AVERT, PROVE-IT, REVERSAL and ALLIANCE, indicate that all statin medical aid in notalike,” said Dr. Michael Koren, director of non-invasive cardiology atMemorial Hospital in Jacksonville, Florida. “Switching patients fromAtorvastatin to otherness less effective medicate s could have negative healthimplications for patients. The IDEAL pharmacoeconomic analysis makes the case that medicate cost savings from use of generic statins may be largely offset by higher patients care and indirect costs.”
The results were presented at the annual American Heart Association Quality of Care and Outcomes Research Meeting in Washington, D.C., and a summary of the data was published in the current issue of “Circulation.”
The newly announced American Heart Association (AHA) and American College of Cardiology (ACC) guidelines on secondary prevention further support LDL reduction. The new guidelines recommend that LDL-cholesterol should be less than 100 mg/dL for all patients with CHD and otherness forms of atherosclerosis vascular illness. In the IDEAL meditate , patients treated with Lipitor achieved average LDL-cholesterol levels of 81 mg/dL which wassignificantly lower than patients taking Zocor, who had an averageLDL-cholesterol level of 104 mg/dL.
Lipitor is the most prescribed cholesterol-lowering medical aid in theworld, with nearly 115 mil. patient-years of experience. Lipitor is a prescription medicate . It is used in patients with multiplerisk factors for heart illness such as family history, high blood pressure, age, low HDL or smoking to reduce the risk of heart attack and stroke. When diet and exercise alone are not enough, Lipitor is used along with a low-fat diet and exercise to lower cholesterol.
Lipitor is also used in patients with type 2 polygenic disease and at least one otherness risk factor for heart illness such as high blood pressure, smoking or complications of polygenic disease, including eye illness and protein in urine, to reduce the risk of heart attack and stroke.
Lipitor is not for everyone. It is not for those with liver problems.And it is not for women who are nursing, pregnant or may become pregnant.
If you take Lipitor, tell your doctor if you feel any new muscle painor weakness. This could be a sign of rare but serious muscle side effects.
Tell your doctor about all medicate s you take. This may help avoidserious medicate interactions. Your doctor should do blood agsdhfgdfs to check your liver function before and during medical aid and may adjust your dose. The most common side effects are gas, constipation, stomach pain and heartburn sickness.
They tend to be mild and often go away.
For additional product information, visit http://www.Lipitor.com
Pfizer Inc
http://www.pfizer.com